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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50302589
Substrate
n/a
Meas. Tech.
ChEMBL_594612 (CHEMBL1037909)
Ki
84±n/a nM
Citation
 Miller, DC; Klute, W; Calabrese, A; Brown, AD Optimising metabolic stability in lipophilic chemical space: the identification of a metabolically stable pyrazolopyrimidine CRF-1 receptor antagonist. Bioorg Med Chem Lett 19:6144-7 (2009) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50302589
Synonyms:
CHEMBL568188 | N-(1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-((propylamino)methyl)-1,2,4-oxadiazol-5-amine
Type:
Small organic molecule
Emp. Form.:
C21H26N8O2
Mol. Mass.:
422.4835
SMILES:
CCCNCc1noc(Nc2nc(C)nc3n(nc(C)c23)-c2ccc(OC)cc2C)n1
Structure:
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