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Target
Egl nine homolog 1
Ligand
BDBM50303767
Substrate
n/a
Meas. Tech.
ChEMBL_597534 (CHEMBL1047009)
Kd
85000±n/a nM
Citation
 Leung, IK; Flashman, E; Yeoh, KK; Schofield, CJ; Claridge, TD Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions. J Med Chem 53:867-75 (2010) [PubMed]  Article 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM50303767
Synonyms:
(2S,5S,8S,11S,14S,17S,20S,23S)-23-(2-((S)-2-((S)-2-((S)-1-((2S,5S,8S,11S,14S,17S,20S)-20-amino-21-carboxy-11-((R)-1-hydroxyethyl)-5,8,14-triisobutyl-2,17-dimethyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazahenicosane)pyrrolidine-2-carboxamido)propanamido)propanamido)acetamido)-2-benzyl-14,17-di-sec-butyl-5-(carboxymethyl)-20-((R)-1-hydroxyethyl)-11-(hydroxymethyl)-8-isobutyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazapentacosane-1,25-dioic acid | CHEMBL578182
Type:
Small organic molecule
Emp. Form.:
C87H141N19O29
Mol. Mass.:
1917.1603
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O |r|
Structure:
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