Target
Neuroendocrine convertase 1
Ligand
BDBM50303774
Substrate
n/a
Meas. Tech.
ChEMBL_597567 (CHEMBL1049704)
Ki
0.750000±n/a nM
Citation
 Becker, GLSielaff, FThan, MELindberg, IRouthier, SDay, RLu, YGarten, WSteinmetzer, T Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem 53:1067-75 (2010) [PubMed]  Article 
Target
Name:
Neuroendocrine convertase 1
Synonyms:
NEC1 | NEC1_HUMAN | PCSK1 | Prohormone convertase 1
Type:
PROTEIN
Mol. Mass.:
84143.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_597567
Residue:
753
Sequence:
MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSPSSSSVGGRRDELEEGAPSQAMLRLLQSAFSKNSPPKQSPKKSPSAKLNIPYENFYEALEKLNKPSQLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEEN
  
Inhibitor
Name:
BDBM50303774
Synonyms:
CHEMBL566340 | phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide
Type:
Small organic molecule
Emp. Form.:
C33H50N12O4
Mol. Mass.:
678.8281
SMILES:
[#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6]-c1ccc(cc1)-[#6](-[#7])=[#7] |r|
Structure:
Search PDB for entries with ligand similarity: