Reaction Details Report a problem with these data
Target
TGF-beta receptor type-1
Ligand
BDBM50304847
Substrate
n/a
Meas. Tech.
ChEMBL_606317 (CHEMBL1070009)
IC50
>10000±n/a nM
Citation
 Guckian, K; Carter, MB; Lin, EY; Choi, M; Sun, L; Boriack-Sjodin, PA; Chuaqui, C; Lane, B; Cheung, K; Ling, L; Lee, WC Pyrazolone based TGFbetaR1 kinase inhibitors. Bioorg Med Chem Lett 20:326-9 (2010) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50304847
Synonyms:
2-(1,2-dimethyl-3-oxo-5-(quinoxalin-6-yl)-2,3-dihydro-1H-pyrazol-4-yl)benzonitrile | CHEMBL603853
Type:
Small organic molecule
Emp. Form.:
C20H15N5O
Mol. Mass.:
341.366
SMILES:
Cn1c(c(-c2ccccc2C#N)c(=O)n1C)-c1ccc2nccnc2c1 |(.9,-4.47,;.27,-3.07,;-1.24,-2.75,;-1.4,-1.22,;-2.74,-.45,;-4.08,-1.22,;-5.41,-.45,;-5.41,1.1,;-4.08,1.87,;-2.74,1.1,;-1.41,1.88,;-.08,2.65,;0,-.59,;.32,.92,;1.04,-1.73,;2.57,-1.57,;-2.56,-3.54,;-3.9,-2.79,;-5.22,-3.58,;-5.19,-5.12,;-6.51,-5.92,;-6.48,-7.46,;-5.13,-8.2,;-3.81,-7.41,;-3.84,-5.87,;-2.53,-5.08,)|
Structure:
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