Target
Beta-secretase 2
Ligand
BDBM50300229
Substrate
n/a
Meas. Tech.
ChEMBL_603777 (CHEMBL1042915)
IC50
770±n/a nM
Citation
 Nowak, PCole, DCAulabaugh, ABard, JChopra, RCowling, RFan, KYHu, BJacobsen, SJani, MJin, GLo, MCMalamas, MSManas, ESNarasimhan, RReinhart, PRobichaud, AJStock, JRSubrath, JSvenson, KTurner, JWagner, EZhou, PEllingboe, JW Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors. Bioorg Med Chem Lett 20:632-5 (2010) [PubMed]  Article 
Target
Name:
Beta-secretase 2
Synonyms:
AEPLC | ALP56 | ASP1 | ASP21 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | BACE2 | BACE2_HUMAN | Beta secretase 2 | Beta-secretase (BACE) | Beta-secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2)
Type:
Protein
Mol. Mass.:
56171.20
Organism:
Homo sapiens (Human)
Description:
Q9Y5Z0
Residue:
518
Sequence:
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
  
Inhibitor
Name:
BDBM50300229
Synonyms:
1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-amine | 2-Imino-3-methyl-5,5-diphenyl-imidazolidin-4-one | 2-amino-1-methyl-4,4-diphenyl-1H-imidazol-5(4H)-one | 5,5-Diphenyl-2-iminohydantoin | CHEMBL291784
Type:
Small organic molecule
Emp. Form.:
C16H15N3O
Mol. Mass.:
265.3098
SMILES:
CN1C(N)=NC(C1=O)(c1ccccc1)c1ccccc1 |c:3|
Structure:
Search PDB for entries with ligand similarity: