Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50306433
Substrate
n/a
Meas. Tech.
ChEMBL_609881 (CHEMBL1073437)
IC50
0.5±n/a nM
Citation
 Tice, CMZhao, WXu, ZCacatian, STSimpson, RDYe, YJSingh, SBMcKeever, BMLindblom, PGuo, JKrosky, PMKruk, BABerbaum, JHarrison, RKJohnson, JJBukhtiyarov, YPanemangalore, RScott, BBZhao, YBruno, JGZhuang, LMcGeehan, GMHe, WClaremon, DA Spirocyclic ureas: orally bioavailable 11beta-HSD1 inhibitors identified by computer-aided drug design. Bioorg Med Chem Lett 20:881-6 (2010) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50306433
Synonyms:
CHEMBL601211 | N-(adamantan-2-yl)-7-bromo-3-(carbamoylmethyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxamide
Type:
Small organic molecule
Emp. Form.:
C26H34BrN3O2
Mol. Mass.:
500.471
SMILES:
n/a
Structure:
Search PDB for entries with ligand similarity: