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Target
Sphingomyelin phosphodiesterase 2
Ligand
BDBM50308978
Substrate
n/a
Meas. Tech.
ChEMBL_611790 (CHEMBL1066447)
IC50
>100000±n/a nM
Citation
 Roth, AG; Redmer, S; Arenz, C Development of carbohydrate-derived inhibitors of acid sphingomyelinase. Bioorg Med Chem 18:939-44 (2010) [PubMed]  Article 
Target
Name:
Sphingomyelin phosphodiesterase 2
Synonyms:
NSMA_RAT | Neutral sphingomyelinase | Smpd2
Type:
PROTEIN
Mol. Mass.:
47651.22
Organism:
Rattus norvegicus
Description:
ChEMBL_611790
Residue:
422
Sequence:
MKHNFSLRLRVFNLNCWDIPYLSKHRADRMKRLGDFLNLESFDLALLEEVWSEQDFQYLKQKLSLTYPDAHYFRSGIIGSGLCVFSRHPIQEIVQHVYTLNGYPYKFYHGDWFCGKAVGLLVLHLSGLVLNAYVTHLHAEYSRQKDIYFAHRVAQAWELAQFIHHTSKKANVVLLCGDLNMHPKDLGCCLLKEWTGLRDAFVETEDFKGSEDGCTMVPKNCYVSQQDLGPFPFGVRIDYVLYKAVSGFHICCKTLKTTTGCDPHNGTPFSDHEALMATLCVKHSPPQEDPCSAHGSAERSALISALREARTELGRGIAQARWWAALFGYVMILGLSLLVLLCVLAAGEEAREVAIMLWTPSVGLVLGAGAVYLFHKQEAKSLCRAQAEIQHVLTRTTETQDLGSEPHPTHCRQQEADRAEEK
  
Inhibitor
Name:
BDBM50308978
Synonyms:
6-O-Ethylsulfonyl-D-glucose-2,4-bisphosphate | CHEMBL590082
Type:
Small organic molecule
Emp. Form.:
C8H18O14P2S
Mol. Mass.:
432.233
SMILES:
CCS(=O)(=O)OC[C@H]1OC(O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O |r|
Structure:
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