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Target
Deoxycytidine kinase
Ligand
BDBM50311540
Substrate
n/a
Meas. Tech.
ChEMBL_618319 (CHEMBL1101183)
IC50
120000±n/a nM
Citation
 Tarver, JE; Jessop, TC; Carlsen, M; Augeri, DJ; Fu, Q; Healy, JP; Heim-Riether, A; Xu, A; Taylor, JA; Shen, M; Keyes, PE; David Kimball, S; Yu, XC; Miranda, M; Liu, Q; Swaffield, JC; Nouraldeen, A; Wilson, AG; Finch, R; Jhaver, K; Foushee, AM; Anderson, S; Oravecz, T; Carson, KG 5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase. Bioorg Med Chem Lett 19:6780-3 (2009) [PubMed]  Article 
Target
Name:
Deoxycytidine kinase
Synonyms:
DCK | DCK_HUMAN
Type:
PROTEIN
Mol. Mass.:
30510.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1437135
Residue:
260
Sequence:
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL
  
Inhibitor
Name:
BDBM50311540
Synonyms:
2'-deoxy-5-fluorocytidine | 4-amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one | CHEMBL1076257
Type:
Small organic molecule
Emp. Form.:
C9H12FN3O4
Mol. Mass.:
245.2077
SMILES:
Nc1nc(=O)n(cc1F)[C@H]1C[C@H](O)[C@@H](CO)O1 |r|
Structure:
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