Reaction Details Report a problem with these data
Target
Low molecular weight protein-tyrosine phosphatase A
Ligand
BDBM50312231
Substrate
n/a
Meas. Tech.
ChEMBL_621991 (CHEMBL1106782)
Ki
65500±n/a nM
Citation
 Rawls, KA; Lang, PT; Takeuchi, J; Imamura, S; Baguley, TD; Grundner, C; Alber, T; Ellman, JA Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Bioorg Med Chem Lett 19:6851-4 (2009) [PubMed]  Article 
Target
Name:
Low molecular weight protein-tyrosine phosphatase A
Synonyms:
PTPA_MYCTU | PTPase | Probable low molecular weight protein-tyrosine-phosphatase | Protein Tyrosine Phosphatase PTPA | mptpA | ptpA
Type:
Hydrolase
Mol. Mass.:
17891.84
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
163
Sequence:
MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
  
Inhibitor
Name:
BDBM50312231
Synonyms:
(4-benzamidophenyl)difluoromethylphosphonic acid | CHEMBL1079495
Type:
Small organic molecule
Emp. Form.:
C14H12F2NO4P
Mol. Mass.:
327.2199
SMILES:
OP(O)(=O)C(F)(F)c1ccc(NC(=O)c2ccccc2)cc1
Structure:
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