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Target
Procathepsin L
Ligand
BDBM50313524
Substrate
n/a
Meas. Tech.
ChEMBL_617676 (CHEMBL1101472)
IC50
>10000±n/a nM
Citation
Rankovic, Z; Cai, J; Fradera, X; Dempster, M; Mistry, A; Mitchell, A; Long, C; Hamilton, E; King, A; Boucharens, S; Jamieson, C; Gillespie, J; Cumming, I; Uitdehaag, J; van Zeeland, M Dioxo-triazines as a novel series of cathepsin K inhibitors. Bioorg Med Chem Lett 20:1488-90 (2010) [PubMed] Article
More Info.:
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Inhibitor
Name:
BDBM50313524
Synonyms:
3,5-dioxo-4-(3-(piperidin-1-yl)propyl)-2-(3-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile | 3,5-dioxo-4-(3-piperidin-1-ylpropyl)-2-[3-(trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile | CHEMBL1084114
Type:
Small organic molecule
Emp. Form.:
C19H20F3N5O2
Mol. Mass.:
407.3896
SMILES:
FC(F)(F)c1cccc(c1)-n1nc(C#N)c(=O)n(CCCN2CCCCC2)c1=O