Reaction Details Report a problem with these data
Target
Death-associated protein kinase 3
Ligand
BDBM50314666
Substrate
n/a
Meas. Tech.
ChEMBL_625624 (CHEMBL1112575)
IC50
713.7±n/a nM
Citation
 Okamoto, M; Takayama, K; Shimizu, T; Muroya, A; Furuya, T Structure-activity relationship of novel DAPK inhibitors identified by structure-based virtual screening. Bioorg Med Chem 18:2728-34 (2010) [PubMed]  Article 
Target
Name:
Death-associated protein kinase 3
Synonyms:
DAP kinase 3 | DAP-like kinase | DAPK3 | DAPK3_HUMAN | ZIP-kinase | ZIPK
Type:
PROTEIN
Mol. Mass.:
52537.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586564
Residue:
454
Sequence:
MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRLKTTRLKEYTIKSHSSLPPNNSYADFERFSKVLEEAAAAEEGLRELQRSRRLCHEDVEALAAIYEEKEAWYREESDSLGQDLRRLRQELLKTEALKRQAQEEAKGALLGTSGLKRRFSRLENRYEALAKQVASEMRFVQDLVRALEQEKLQGVECGLR
  
Inhibitor
Name:
BDBM50314666
Synonyms:
4-(pyridin-3-ylmethylene)-2-m-tolyloxazol-5(4H)-one | CHEMBL1091786
Type:
Small organic molecule
Emp. Form.:
C16H12N2O2
Mol. Mass.:
264.2787
SMILES:
Cc1cccc(c1)C1=N\C(=C/c2cccnc2)C(=O)O1 |t:8|
Structure:
Search PDB for entries with ligand similarity: