Reaction Details Report a problem with these data
Target
Histamine H1 receptor
Ligand
BDBM50315207
Substrate
n/a
Meas. Tech.
ChEMBL_625162 (CHEMBL1115183)
Ki
2.2±n/a nM
Citation
 Li, BF; Moree, WJ; Yu, J; Coon, T; Zamani-Kord, S; Malany, S; Jalali, K; Wen, J; Wang, H; Yang, C; Hoare, SR; Petroski, RE; Madan, A; Crowe, PD; Beaton, G Selectivity profiling of novel indene H(1)-antihistamines for the treatment of insomnia. Bioorg Med Chem Lett 20:2629-33 (2010) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM50315207
Synonyms:
(R)-N,N-dimethyl-2-(6-methyl-3-(1-(thiazol-2-yl)ethyl)-1H-inden-2-yl)ethanamine | CHEMBL1090528
Type:
Small organic molecule
Emp. Form.:
C19H24N2S
Mol. Mass.:
312.472
SMILES:
C[C@H](C1=C(CCN(C)C)Cc2cc(C)ccc12)c1nccs1 |r,c:2|
Structure:
Search PDB for entries with ligand similarity: