Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50315643
Substrate
n/a
Meas. Tech.
ChEMBL_623793 (CHEMBL1117076)
Ki
0.108±n/a nM
Citation
 Cheong, SL; Dolzhenko, A; Kachler, S; Paoletta, S; Federico, S; Cacciari, B; Dolzhenko, A; Klotz, KN; Moro, S; Spalluto, G; Pastorin, G The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition. J Med Chem 53:3361-75 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50315643
Synonyms:
CHEMBL1091268 | N-[2-(Phenyl)-8-methylpyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]phenylacetamide
Type:
Small organic molecule
Emp. Form.:
C21H17N7O
Mol. Mass.:
383.406
SMILES:
Cn1cc2c(n1)nc(NC(=O)Cc1ccccc1)n1nc(nc21)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: