Reaction Details Report a problem with these data
Target
Arginase-1
Ligand
BDBM50316603
Substrate
n/a
Meas. Tech.
ChEMBL_631953 (CHEMBL1104709)
Kd
2000±n/a nM
Citation
 Ilies, M; Di Costanzo, L; North, ML; Scott, JA; Christianson, DW 2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I. J Med Chem 53:4266-76 (2010) [PubMed]  Article 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM50316603
Synonyms:
2-(S)-amino-5-(2-aminoimidazol-1-yl)pentanoic acid | CHEMBL1099169
Type:
Small organic molecule
Emp. Form.:
C8H14N4O2
Mol. Mass.:
198.2224
SMILES:
N[C@@H](CCCn1ccnc1N)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: