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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50316690
Substrate
n/a
Meas. Tech.
ChEMBL_632234 (CHEMBL1110096)
IC50
1.4±n/a nM
Citation
 Childers, WE; Havran, LM; Asselin, M; Bicksler, JJ; Chong, DC; Grosu, GT; Shen, Z; Abou-Gharbia, MA; Bach, AC; Harrison, BL; Kagan, N; Kleintop, T; Magolda, R; Marathias, V; Robichaud, AJ; Sabb, AL; Zhang, MY; Andree, TH; Aschmies, SH; Beyer, C; Comery, TA; Day, M; Grauer, SM; Hughes, ZA; Rosenzweig-Lipson, S; Platt, B; Pulicicchio, C; Smith, DE; Sukoff-Rizzo, SJ; Sullivan, KM; Adedoyin, A; Huselton, C; Hirst, WD The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists. J Med Chem 53:4066-84 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50316690
Synonyms:
8-{4-[4-(6-Methoxyquinolin-8-yl)piperazin-1-yl]piperidin-1-yl}-4-methylquinoline | CHEMBL1094558
Type:
Small organic molecule
Emp. Form.:
C29H33N5O
Mol. Mass.:
467.6052
SMILES:
COc1cc(N2CCN(CC2)C2CCN(CC2)c2cccc3c(C)ccnc23)c2ncccc2c1
Structure:
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