Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-beta
Ligand
BDBM50317733
Substrate
n/a
Meas. Tech.
ChEMBL_629445 (CHEMBL1105798)
EC50
284±n/a nM
Citation
 Ullrich, JW; Morris, R; Bernotas, RC; Travins, JM; Jetter, J; Unwalla, R; Quinet, E; Nambi, P; Feingold, I; Huselton, C; Enroth, C; Wilhelmsson, A; Goos-Nilsson, A; Wrobel, J Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists. Bioorg Med Chem Lett 20:2903-7 (2010) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50317733
Synonyms:
3-methyl-4-(3'-(methylsulfonyl)biphenyl-3-yl)-8-(trifluoromethyl)quinoline | CHEMBL1094741
Type:
Small organic molecule
Emp. Form.:
C24H18F3NO2S
Mol. Mass.:
441.465
SMILES:
Cc1cnc2c(cccc2c1-c1cccc(c1)-c1cccc(c1)S(C)(=O)=O)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: