Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50273099
Substrate
n/a
Meas. Tech.
ChEMBL_633683 (CHEMBL1118308)
EC50
286±n/a nM
Citation
 Boatman, PD; Schrader, TO; Kasem, M; Johnson, BR; Skinner, PJ; Jung, JK; Xu, J; Cherrier, MC; Webb, PJ; Semple, G; Sage, CR; Knudsen, J; Chen, R; Taggart, AK; Carballo-Jane, E; Richman, JG Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a). Bioorg Med Chem Lett 20:2797-800 (2010) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM50273099
Synonyms:
3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole | 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole | CHEMBL456145 | MK-0354
Type:
Small organic molecule
Emp. Form.:
C7H8N6
Mol. Mass.:
176.1786
SMILES:
C1Cc2[nH]nc(c2C1)-c1nnn[nH]1
Structure:
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