Target
Aurora kinase B
Ligand
BDBM8066
Substrate
n/a
Meas. Tech.
ChEMBL_634452 (CHEMBL1119478)
Ki
15±n/a nM
Citation
 Wang, SMidgley, CAScaërou, FGrabarek, JBGriffiths, GJackson, WKontopidis, GMcClue, SJMcInnes, CMeades, CMezna, MPlater, AStuart, IThomas, MPWood, GClarke, RGBlake, DGZheleva, DILane, DPJackson, RCGlover, DMFischer, PM Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors. J Med Chem 53:4367-78 (2010) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM8066
Synonyms:
2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1-N-dimethylbenzene-1,4-diamine, 3 | 4-N-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1-N-dimethylbenzene-1,4-diamine | N-[4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-yl]N,N-dimethylbenzene-1,4-diamine
Type:
Small organic molecule
Emp. Form.:
C17H19N5S
Mol. Mass.:
325.431
SMILES:
CN(C)c1ccc(Nc2nccc(n2)-c2sc(C)nc2C)cc1
Structure:
Search PDB for entries with ligand similarity: