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TargetAldo-keto reductase family member 1B10 (AKR1B10)
LigandBDBM50321718
Substrate/Competitorn/a
Meas. Tech.ChEMBL_640034
Ki 12±n/a nM
Citation Endo, SMatsunaga, TKuwata, KZhao, HTEl-Kabbani, OKitade, YHara, A Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. Bioorg Med Chem18:2485-90 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldo-keto reductase family member 1B10 (AKR1B10)
Name:Aldo-keto reductase family member 1B10 (AKR1B10)
Synonyms:ARL-1 | ARP | Aldo-keto reductase family 1 member B10 | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldose reductase-like | Aldose reductase-related protein | SI reductase | Small intestine reductase | hARP
Type:Protein
Mol. Mass.:36024.67
Organism:Homo sapiens (Human)
Description:O60218. 1ZUA; 4JII; 4GQ0
Residue:316
Sequence:
MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQ
EKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD
DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP
VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK
HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN
VLQSSHLEDYPFNAEY
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  Blast E-value cutoff:
BDBM50321718
NameBDBM50321718
Synonyms:2-(2,4-dimethoxyphenylimino)-7-hydroxy-N-(pyridin-2-yl)-2H-chromene-3-carboxamide | CHEMBL1171546
TypeSmall organic molecule
Emp. Form.C23H19N3O5
Mol. Mass.417.4141
SMILESCOc1ccc(\N=c2/oc3cc(O)ccc3cc2C(=O)Nc2ccccn2)c(OC)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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