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Target
Beta-lactamase
Ligand
BDBM50324682
Substrate
n/a
Meas. Tech.
ChEMBL_650320 (CHEMBL1224978)
Ki
1000±n/a nM
Citation
 Babaoglu, K; Shoichet, BK Deconstructing fragment-based inhibitor discovery. Nat Chem Biol 2:720-3 (2006) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_ECOLI | Beta-lactamase | Beta-lactamase (AmpC) | Beta-lactamase AmpC | Cephalosporinase | Escherichia coli K-12 | ampA | ampC
Type:
Protien
Mol. Mass.:
41561.62
Organism:
Escherichia coli
Description:
P00811
Residue:
377
Sequence:
MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ
  
Inhibitor
Name:
BDBM50324682
Synonyms:
3-(N-(4-carboxy-2-hydroxyphenyl)sulfamoyl)thiophene-2-carboxylic acid | 3-{[(4-CARBOXY-2-HYDROXYANILINE]SULFONYL}THIOPHENE-2-CARBOXYLIC ACID | CHEMBL1222313
Type:
Small organic molecule
Emp. Form.:
C12H9NO7S2
Mol. Mass.:
343.332
SMILES:
OC(=O)c1sccc1S(=O)(=O)Nc1ccc(cc1O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: