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TargetIndoleamine 2,3-dioxygenase 1
LigandBDBM50324700
Substrate/Competitorn/a
Meas. Tech.ChEMBL_650626
Ki 80±n/a nM
Citation Volgraf, MLumb, JPBrastianos, HCCarr, GChung, MKMünzel, MMauk, AGAndersen, RJTrauner, D Biomimetic synthesis of the IDO inhibitors exiguamine A and B. Nat Chem Biol4:535-7 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Indoleamine 2,3-dioxygenase 1
Name:Indoleamine 2,3-dioxygenase
Synonyms:IDO | IDO-1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase
Type:Enzyme
Mol. Mass.:45330.80
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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  Blast E-value cutoff:
BDBM50324700
NameBDBM50324700
Synonyms:CHEMBL1221412 | Exiguamine B
TypeSmall organic molecule
Emp. Form.C25H26N5O7
Mol. Mass.508.5027
SMILESCN1C(=O)N(C)[C@]2(Oc3c(O)cc4c([C@H](O)C[N+]4(C)C)c3C3=C2C(=O)c2c(CCN)c[nH]c2C3=O)C1=O |r,c:23|
Structure
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n/a