Target
Corticotropin-releasing factor receptor 2
Ligand
BDBM50318666
Substrate
n/a
Meas. Tech.
ChEMBL_658544 (CHEMBL1247746)
IC50
>30000±n/a nM
Citation
 Rottmann, MMcNamara, CYeung, BKLee, MCZou, BRussell, BSeitz, PPlouffe, DMDharia, NVTan, JCohen, SBSpencer, KRGonzález-Páez, GELakshminarayana, SBGoh, ASuwanarusk, RJegla, TSchmitt, EKBeck, HPBrun, RNosten, FRenia, LDartois, VKeller, THFidock, DAWinzeler, EADiagana, TT Spiroindolones, a potent compound class for the treatment of malaria. Science 329:1175-80 (2010) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 2
Synonyms:
CRF-R 2 | CRF2 | CRF2R | CRFR2_HUMAN | CRH-R 2 | CRH2R | CRHR2 | Corticotropin releasing factor receptor 2 | Corticotropin-releasing factor receptor 2 (CRF-2) | Corticotropin-releasing factor receptor 2/Corticotropin-releasing factor-binding protein | Corticotropin-releasing hormone receptor 2
Type:
Enzyme
Mol. Mass.:
47694.70
Organism:
Homo sapiens (Human)
Description:
Q13324
Residue:
411
Sequence:
MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
  
Inhibitor
Name:
BDBM50318666
Synonyms:
(1R,3S)-5',7-Dichloro-6-fluoro-3-methyl-2,3,4,9-tetrahydrospiro-[beta-carboline-1,3'-indol]-2'(1'H)-one | CHEMBL1082723 | NITD609
Type:
Small organic molecule
Emp. Form.:
C19H14Cl2FN3O
Mol. Mass.:
390.238
SMILES:
C[C@H]1Cc2c([nH]c3cc(Cl)c(F)cc23)[C@@]2(N1)C(=O)Nc1ccc(Cl)cc21 |r|
Structure:
Search PDB for entries with ligand similarity: