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Target
MHC class II antigen
Ligand
BDBM50326699
Substrate
n/a
Meas. Tech.
ChEMBL_661466 (CHEMBL1252964)
IC50
4±n/a nM
Citation
 Venkatraman, P; Nguyen, TT; Sainlos, M; Bilsel, O; Chitta, S; Imperiali, B; Stern, LJ Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells. Nat Chem Biol 3:222-8 (2007) [PubMed]  Article 
Target
Name:
MHC class II antigen
Synonyms:
DR-1 | DR1 | HLA class II histocompatibility antigen DRB1-1 | HLA class II histocompatibility antigen, DRB1-1 beta chain | Human leukocyte antigen DR beta chain | MHC class I antigen DRB1*1
Type:
PROTEIN
Mol. Mass.:
29917.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_192854
Residue:
266
Sequence:
MVCLKLPGGSCMTALTVTLMVLSSPLALAGDTRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNYGVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS
  
Inhibitor
Name:
BDBM50326699
Synonyms:
(2S,5S,8S,11S,14S,17S,20S,23S,26S)-2-amino-1-(5-(dimethylamino)-1,3-dioxoisoindolin-2-yl)-5-(3-guanidinopropyl)-8-(hydroxymethyl)-14,17,20,23,28-pentamethyl-11-(2-(methylthio)ethyl)-3,6,9,12,15,18,21,24-octaoxo-4,7,10,13,16,19,22,25-octaazanonacosane-26-carboxylic acid | CHEMBL1253322
Type:
Small organic molecule
Emp. Form.:
C45H72N14O13S
Mol. Mass.:
1049.204
SMILES:
[#6]-[#16]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#7]-1-[#6](=O)-c2ccc(cc2-[#6]-1=O)-[#7](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](-[#8])=O |r|
Structure:
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