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TargetG-protein coupled bile acid receptor 1
LigandBDBM50327520
Substrate/Competitorn/a
Meas. Tech.ChEMBL_664648
IC50 580±n/a nM
Citation Herbert, MRSiegel, DLStaszewski, LCayanan, CBanerjee, UDhamija, SAnderson, JFan, AWang, LRix, PShiau, AKRao, TSNoble, SAHeyman, RABischoff, EGuha, MKabakibi, APinkerton, AB Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5. Bioorg Med Chem Lett20:5718-21 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
G-protein coupled bile acid receptor 1
Name:G-protein coupled bile acid receptor 1
Synonyms:BG37 | M-BAR | TGR5 | hBG37 | hGPCR19
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:35260.02
Organism:Homo sapiens (Human)
Description:CHO cells transiently transfected with hTGR5.
Residue:330
Sequence:
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA
GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP
PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA
AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY
VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ
GLWGRASRDSPGPSIAYHPSSQSSVDLDLN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50327520
NameBDBM50327520
Synonyms:CHEMBL1258310 | N-(4-chlorobenzyl)-1-(7-methoxy-2-(thiophen-3-yl)quinolin-3-yl)methanamine
TypeSmall organic molecule
Emp. Form.C22H19ClN2OS
Mol. Mass.394.917
SMILESCOc1ccc2cc(CNCc3ccc(Cl)cc3)c(nc2c1)-c1ccsc1
Structure
n/a