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Target
Isocitrate lyase
Ligand
BDBM50329694
Substrate
n/a
Meas. Tech.
ChEMBL_675509 (CHEMBL1273722)
IC50
22580±n/a nM
Citation
 Oh, KB; Jeon, HB; Han, YR; Lee, YJ; Park, J; Lee, SH; Yang, D; Kwon, M; Shin, J; Lee, HS Bromophenols as Candida albicans isocitrate lyase inhibitors. Bioorg Med Chem Lett 20:6644-8 (2010) [PubMed]  Article 
Target
Name:
Isocitrate lyase
Synonyms:
ACEA_CANAX | ICL1
Type:
PROTEIN
Mol. Mass.:
61398.95
Organism:
Candida albicans
Description:
ChEMBL_972063
Residue:
550
Sequence:
MPYTPIDIQKEEADFQKEVAEIKKWWSEPRWRKTKRIYSAEDIAKKRGTLKINHPSSQQADKLFKLLETHDADKTVSFTFGALDPIHVAQMAKYLDSIYVSGWQCSSTASTSNEPSPDLADYPMDTVPNKVEHLWFAQLFHDRKQREERLTLSKEERAKTPYIDFLRPIIADADTGHGGITAIIKLTKMFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPVQEHINRLVAIRASADIFGSNLLAVARTDSEAATLITSTIDHRDHYFIIGATNPEAGDLAALMAEAESKGIYGNELAAIESEWTKKAGLKLFHEAVIDEIKNGNYSNKDALIKKFTDKVNPLSHTSHKEAKKLAKELTGKDIYFNWDVARAREGYYRYQGGTQCAVMRGRAFAPYADLIWMESALPDYAQAKEFADGVKAAVPDQWLAYNLSPSFNWNKAMPADEQETYIKRLGKLGYVWQFITLAGLHTTALAVDDFSNQYSQIGMKAYGQTVQQPEIEKGVEVVKHQKWSGATYIDGLLKMVSGGVTSTAAMGQGVTEDQFKESKAKA
  
Inhibitor
Name:
BDBM50329694
Synonyms:
Bis(3,4-dihydroxyphenyl)methanone | CHEMBL1269420 | hCA inhibitor, 3
Type:
Small organic molecule
Emp. Form.:
C13H10O5
Mol. Mass.:
246.2155
SMILES:
Oc1ccc(cc1O)C(=O)c1ccc(O)c(O)c1
Structure:
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