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Target
5-hydroxytryptamine receptor 5A
Ligand
BDBM50330813
Substrate
n/a
Meas. Tech.
ChEMBL_685492 (CHEMBL1285523)
IC50
>1000±n/a nM
Citation
 King, HD; Meng, Z; Deskus, JA; Sloan, CP; Gao, Q; Beno, BR; Kozlowski, ES; Lapaglia, MA; Mattson, GK; Molski, TF; Taber, MT; Lodge, NJ; Mattson, RJ; Macor, JE Conformationally restricted homotryptamines. Part 7: 3-cis-(3-aminocyclopentyl)indoles as potent selective serotonin reuptake inhibitors. J Med Chem 53:7564-72 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 5A
Synonyms:
5-HT-5 | 5-HT-5A | 5-hydroxytryptamine receptor 5 (5-HT5) | 5-hydroxytryptamine receptor 5A (5-HT5A) | 5HT5A_HUMAN | HTR5A | Serotonin (5-HT) receptor | Serotonin receptor 5A
Type:
Enzyme
Mol. Mass.:
40266.25
Organism:
Homo sapiens (Human)
Description:
P47898
Residue:
357
Sequence:
MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
  
Inhibitor
Name:
BDBM50330813
Synonyms:
3-[(1S,3R)-3-Dimethylaminocyclopentyl]-1H-indole-5-carbonitrile | CHEMBL1275709
Type:
Small organic molecule
Emp. Form.:
C16H19N3
Mol. Mass.:
253.3422
SMILES:
CN(C)[C@@H]1CC[C@@H](C1)c1c[nH]c2ccc(cc12)C#N |r|
Structure:
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