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Target
Serine/threonine-protein kinase Nek3
Ligand
BDBM50331612
Substrate
n/a
Meas. Tech.
ChEMBL_687477 (CHEMBL1292153)
Ki
>1000000±n/a nM
Citation
 Krug, M; Erlenkamp, G; Sippl, W; Schächtele, C; Totzke, F; Hilgeroth, A Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett 20:6915-9 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Nek3
Synonyms:
NEK3 | NEK3_HUMAN
Type:
PROTEIN
Mol. Mass.:
57709.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774350
Residue:
506
Sequence:
MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRIALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTDFEEEDDNPDWVSELKKRAGWQGLCDR
  
Inhibitor
Name:
BDBM50331612
Synonyms:
CHEMBL1290072 | N-(4-methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
Type:
Small organic molecule
Emp. Form.:
C19H16N2O2
Mol. Mass.:
304.3425
SMILES:
COc1ccc(CNc2ccnc3oc4ccccc4c23)cc1
Structure:
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