Target
Ribosyldihydronicotinamide dehydrogenase [quinone]
Ligand
BDBM50332189
Substrate
n/a
Meas. Tech.
ChEMBL_687953
IC50
2900±n/a nM
Citation
 Nolan, KACaraher, MCHumphries, MPBettley, HABryce, RAStratford, IJ In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett 20:7331-6 (2010) [PubMed]  Article
Target
Name:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Synonyms:
Metallothionein-3 | NRH dehydrogenase [quinone] 2 | NRH:quinone oxidoreductase 2 | QR2 | Quinone reductase 2 | Quinone reductase 2 (NQO2) | Ribosyldihydronicotinamide dehydrogenase [quinone]
Type:
Protein
Mol. Mass.:
25917.25
Organism:
Homo sapiens (Human)
Description:
P16083
Residue:
231
Sequence:
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
  
Inhibitor
Name:
BDBM50332189
Synonyms:
14H-diindolo[2,3-a:3',2'-h]quinolizine | CHEMBL1287982 | NSC-677939
Type:
Small organic molecule
Emp. Form.:
C21H13N3
Mol. Mass.:
307.348
SMILES:
c1ccc2c(c1)nc1c2ccn2ccc3c4ccccc4[nH]c3c12
Structure:
Search PDB for entries with ligand similarity: