Target
Histamine H3 receptor
Ligand
BDBM50333508
Substrate
n/a
Meas. Tech.
ChEMBL_699500 (CHEMBL1647755)
Ki
62±n/a nM
Citation
 Xiao, DPalani, ASofolarides, MHuang, YAslanian, RVaccaro, HHong, LMcKittrick, BWest, REWilliams, SMWu, RLHwa, JSondey, CLachowicz, J Discovery of a series of potent arylthiadiazole H(3) antagonists. Bioorg Med Chem Lett 21:861-4 (2011) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50333508
Synonyms:
2-(1,4'-bipiperidin-1'-yl)-5-(3-fluorophenyl)-1,3,4-thiadiazole | CHEMBL1641825
Type:
Small organic molecule
Emp. Form.:
C18H23FN4S
Mol. Mass.:
346.465
SMILES:
Fc1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: