Reaction Details Report a problem with these data
Target
Adenosylhomocysteinase
Ligand
BDBM50336550
Substrate
n/a
Meas. Tech.
ChEMBL_725342 (CHEMBL1676754)
IC50
>1000000±n/a nM
Citation
 Lee, KM; Choi, WJ; Lee, Y; Lee, HJ; Zhao, LX; Lee, HW; Park, JG; Kim, HO; Hwang, KY; Heo, YS; Choi, S; Jeong, LS X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues. J Med Chem 54:930-8 (2011) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50336550
Synonyms:
5-(6-Aminopurin-9-yl)-4-chlorocyclopent-3-ene-1,2-diol | CHEMBL1672011
Type:
Small organic molecule
Emp. Form.:
C10H10ClN5O2
Mol. Mass.:
267.672
SMILES:
Nc1ncnc2n(cnc12)[C@H]1[C@H](O)[C@H](O)C=C1Cl |r,c:17|
Structure:
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