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Target
Kappa-type opioid receptor
Ligand
BDBM50336669
Substrate
n/a
Meas. Tech.
ChEMBL_722916 (CHEMBL1674427)
Ki
0.228±n/a nM
Citation
 Nemoto, T; Yamamoto, N; Watanabe, A; Fujii, H; Hasebe, K; Nakajima, M; Mochizuki, H; Nagase, H Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies. Bioorg Med Chem 19:1205-21 (2011) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50336669
Synonyms:
CHEMBL1672477 | N-[(6beta,14beta-Epoxy-3-hydroxy-17-methylmorphinan-6alpha-yl)methyl]benzamide
Type:
Small organic molecule
Emp. Form.:
C25H28N2O3
Mol. Mass.:
404.5014
SMILES:
CN1CC[C@]23C[C@]4(CNC(=O)c5ccccc5)CC[C@@]2(O4)[C@H]1Cc1ccc(O)cc31 |r,THB:0:1:19:29.23.22|
Structure:
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