Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50340434
Substrate
n/a
Meas. Tech.
ChEMBL_741129 (CHEMBL1764400)
IC50
1000±n/a nM
Citation
 Venier, OPascal, CBraun, ANamane, CMougenot, PCrespin, OPacquet, FMougenot, CMonseau, COnofri, BDadji-Faïhun, RLeger, CBen-Hassine, MVan-Pham, TRagot, JLPhilippo, CGüssregen, SEngel, CFarjot, GNoah, LManiani, KNicolaï, E Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1. Bioorg Med Chem Lett 21:2244-51 (2011) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mus musculus (mouse)
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
  
Inhibitor
Name:
BDBM50340434
Synonyms:
(4-(1H-pyrazol-3-yl)piperidin-1-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone | CHEMBL1761847
Type:
Small organic molecule
Emp. Form.:
C18H22N4O
Mol. Mass.:
310.3935
SMILES:
O=C(N1CCC(CC1)c1ccn[nH]1)N1CCCc2ccccc12
Structure:
Search PDB for entries with ligand similarity: