Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50340443
Substrate
n/a
Meas. Tech.
ChEMBL_741128 (CHEMBL1764399)
IC50
9±n/a nM
Citation
 Venier, OPascal, CBraun, ANamane, CMougenot, PCrespin, OPacquet, FMougenot, CMonseau, COnofri, BDadji-Faïhun, RLeger, CBen-Hassine, MVan-Pham, TRagot, JLPhilippo, CGüssregen, SEngel, CFarjot, GNoah, LManiani, KNicolaï, E Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1. Bioorg Med Chem Lett 21:2244-51 (2011) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50340443
Synonyms:
(3-(1H-pyrazol-4-yl)pyrrolidin-1-yl)(4-methyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone | CHEMBL1761864
Type:
Small organic molecule
Emp. Form.:
C17H21N5O
Mol. Mass.:
311.3815
SMILES:
CN1CCN(C(=O)N2CCC(C2)c2cn[nH]c2)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: