Reaction Details Report a problem with these data
Target
Somatostatin receptor type 2
Ligand
BDBM50341559
Substrate
n/a
Meas. Tech.
ChEMBL_743882 (CHEMBL1767825)
Ki
1400±n/a nM
Citation
 Wolkenberg, SE; Zhao, Z; Thut, C; Maxwell, JW; McDonald, TP; Kinose, F; Reilly, M; Lindsley, CW; Hartman, GD Design, synthesis, and evaluation of novel 3,6-diaryl-4-aminoalkoxyquinolines as selective agonists of somatostatin receptor subtype 2. J Med Chem 54:2351-8 (2011) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS-2-R | SS2-R | SS2R | SSR2_HUMAN | SSTR2 | Somatostatin receptor type 2 (SSTR2)
Type:
Enzyme
Mol. Mass.:
41344.94
Organism:
Homo sapiens (Human)
Description:
P30874
Residue:
369
Sequence:
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Inhibitor
Name:
BDBM50341559
Synonyms:
7-chloro-3-(3,5-dimethylphenyl)-4-(2-(piperidin-2-yl)ethoxy)-6-(pyrimidin-4-yl)quinolin-2(1H)-one | CHEMBL1766106
Type:
Small organic molecule
Emp. Form.:
C28H29ClN4O2
Mol. Mass.:
489.008
SMILES:
Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[nH]c1=O)-c1ccncn1
Structure:
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