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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50342392
Substrate
n/a
Meas. Tech.
ChEMBL_743061 (CHEMBL1768532)
IC50
40±n/a nM
Citation
 Pevet, I; Brulé, C; Tizot, A; Gohier, A; Cruzalegui, F; Boutin, JA; Goldstein, S Synthesis and pharmacological evaluation of thieno[2,3-b]pyridine derivatives as novel c-Src inhibitors. Bioorg Med Chem 19:2517-28 (2011) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50342392
Synonyms:
3-Amino-4-benzyl-6-(2-dimethylamino-ethylamino)-thieno[2,3-b]pyridine-2-carboxylic acid(1-methyl-1H-pyrrol-2-yl-methylene)-hydrazide | CHEMBL1765560
Type:
Small organic molecule
Emp. Form.:
C25H29N7OS
Mol. Mass.:
475.609
SMILES:
CN(C)CCNc1cc(Cc2ccccc2)c2c(N)c(sc2n1)C(=O)N\N=C\c1cccn1C
Structure:
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