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Target
Acid-sensing ion channel 3
Ligand
BDBM50342643
Substrate
n/a
Meas. Tech.
ChEMBL_745055 (CHEMBL1772131)
IC50
7100±n/a nM
Citation
 Wolkenberg, SE; Zhao, Z; Mulhearn, JJ; Harrison, ST; Sanders, JM; Cato, MJ; Jovanovska, A; Panigel, J; Cook, SP; Henze, DA; Kane, SA; Hartman, GD; Barrow, JC High concentration electrophysiology-based fragment screen: discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors. Bioorg Med Chem Lett 21:2646-9 (2011) [PubMed]  Article 
Target
Name:
Acid-sensing ion channel 3
Synonyms:
ACCN3 | ASIC3 | ASIC3_HUMAN | Amiloride-sensitive cation channel 3 | SLNAC1 | TNAC1
Type:
PROTEIN
Mol. Mass.:
58910.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_757561
Residue:
531
Sequence:
MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL
  
Inhibitor
Name:
BDBM50342643
Synonyms:
6-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline | CHEMBL1770746
Type:
Small organic molecule
Emp. Form.:
C16H14F3N
Mol. Mass.:
277.2843
SMILES:
FC(F)(F)c1cccc(c1)-c1ccc2CNCCc2c1
Structure:
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