Target
Histamine H4 receptor
Ligand
BDBM50304527
Substrate
n/a
Meas. Tech.
ChEMBL_744294 (CHEMBL1772151)
Ki
20±n/a nM
Citation
 Meduna, SPSavall, BMCai, HEdwards, JPThurmond, RLMcGovern, PM Triamino pyrimidines and pyridines as histamine H(4) receptor modulators. Bioorg Med Chem Lett 21:3113-6 (2011) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50304527
Synonyms:
CHEMBL492677 | N4-Benzyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
Type:
Small organic molecule
Emp. Form.:
C16H22N6
Mol. Mass.:
298.3861
SMILES:
CN1CCN(CC1)c1cc(NCc2ccccc2)nc(N)n1
Structure:
Search PDB for entries with ligand similarity: