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Target
Histamine H4 receptor
Ligand
BDBM50342989
Substrate
n/a
Meas. Tech.
ChEMBL_744295 (CHEMBL1772152)
EC50
>10000±n/a nM
Citation
 Meduna, SP; Savall, BM; Cai, H; Edwards, JP; Thurmond, RL; McGovern, PM Triamino pyrimidines and pyridines as histamine H(4) receptor modulators. Bioorg Med Chem Lett 21:3113-6 (2011) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50342989
Synonyms:
CHEMBL1771000 | N4-isobutyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
Type:
Small organic molecule
Emp. Form.:
C13H24N6
Mol. Mass.:
264.3699
SMILES:
CC(C)CNc1cc(nc(N)n1)N1CCN(C)CC1
Structure:
Search PDB for entries with ligand similarity: