Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50343620
Substrate
n/a
Meas. Tech.
ChEMBL_746382 (CHEMBL1776341)
Ki
0.8±n/a nM
Citation
 Li, ZJRen, HYCui, MCDeuther-Conrad, WTang, RKSteinbach, JBrust, PLiu, BLJia, HM Synthesis and biological evaluation of novel 4-benzylpiperazine ligands for sigma-1 receptor imaging. Bioorg Med Chem 19:2911-7 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50343620
Synonyms:
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-iodobenzyl)piperazine | CHEMBL1774730
Type:
Small organic molecule
Emp. Form.:
C19H21IN2O2
Mol. Mass.:
436.2867
SMILES:
Ic1ccc(CN2CCN(Cc3ccc4OCOc4c3)CC2)cc1
Structure:
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