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Target
Synaptic vesicular amine transporter
Ligand
BDBM50344443
Substrate
n/a
Meas. Tech.
ChEMBL_747696 (CHEMBL1780851)
Ki
22.4±n/a nM
Citation
 Zheng, P; Lieberman, BP; Choi, SR; Plöessl, K; Kung, HF Synthesis and biological evaluation of 3-alkyl-dihydrotetrabenazine derivatives as vesicular monoamine transporter-2 (VMAT2) ligands. Bioorg Med Chem Lett 21:3435-8 (2011) [PubMed]  Article 
Target
Name:
Synaptic vesicular amine transporter
Synonyms:
Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2
Type:
Protein
Mol. Mass.:
55689.58
Organism:
Rattus norvegicus (Rat)
Description:
Q01827
Residue:
515
Sequence:
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
  
Inhibitor
Name:
BDBM50344443
Synonyms:
CHEMBL1780009 | rac-(2R)-9-(3-fluoropropoxy)-10-methoxy-3-(prop-1-enyl)-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol
Type:
Small organic molecule
Emp. Form.:
C20H28FNO3
Mol. Mass.:
349.4396
SMILES:
COc1cc2C3C[C@@H](O)C(CN3CCc2cc1OCCCF)\C=C\C |r|
Structure:
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