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Target
Programmed cell death protein 4
Ligand
BDBM36609
Substrate
n/a
Meas. Tech.
ChEMBL_751484 (CHEMBL1787264)
EC50
50±n/a nM
Citation
 Grkovic, T; Blees, JS; Colburn, NH; Schmid, T; Thomas, CL; Henrich, CJ; McMahon, JB; Gustafson, KR Cryptocaryols A-H,a-pyrone-containing 1,3-polyols from Cryptocarya sp. implicated in stabilizing the tumor suppressor Pdcd4. J Nat Prod 74:1015-20 (2011) [PubMed]  Article 
Target
Name:
Programmed cell death protein 4
Synonyms:
H731 | Neoplastic transformation inhibitor protein | Nuclear antigen H731-like | PDCD4 | PDCD4_HUMAN | Protein 197/15a
Type:
PROTEIN
Mol. Mass.:
51720.55
Organism:
Homo sapiens (Human)
Description:
ChEMBL_776474
Residue:
469
Sequence:
MDVENEQILNVNPADPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY
  
Inhibitor
Name:
BDBM36609
Synonyms:
Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, Compound Ramycin
Type:
Small organic molecule
Emp. Form.:
C51H79NO13
Mol. Mass.:
914.1719
SMILES:
CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1O |c:14,33,t:29,31|
Structure:
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