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Target
D(1A) dopamine receptor
Ligand
BDBM50346377
Substrate
n/a
Meas. Tech.
ChEMBL_749997 (CHEMBL1787135)
Ki
>10000±n/a nM
Citation
 Fiorino, F; Magli, E; Perissutti, E; Severino, B; Frecentese, F; Esposito, A; De Angelis, F; Incisivo, GM; Massarelli, P; Nencini, C; Di Gennaro, E; Budillon, A; Di Cintio, A; Santagada, V; Caliendo, G Synthesis of 1-naphtylpiperazine derivatives as serotoninergic ligands and their evaluation as antiproliferative agents. Eur J Med Chem 46:2206-16 (2011) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49429.75
Organism:
RAT
Description:
P18901
Residue:
446
Sequence:
MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
  
Inhibitor
Name:
BDBM50346377
Synonyms:
4-[2-[4-(naphthalen)piperazin-1-yl]ethoxy]-4-aza-tricyclo [5.2.1.02,6]dec-8-ene-3,5-dione | CHEMBL1783350
Type:
Small organic molecule
Emp. Form.:
C25H27N3O3
Mol. Mass.:
417.5002
SMILES:
O=C1C2C3CC(C=C3)C2C(=O)N1OCCN1CCN(CC1)c1cccc2ccccc12 |c:6|
Structure:
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