Target
Matrix metalloproteinase-25
Ligand
BDBM50346797
Substrate
n/a
Meas. Tech.
ChEMBL_753772 (CHEMBL1799653)
IC50
34±n/a nM
Citation
 Nuti, ECasalini, FSantamaria, SGabelloni, PBendinelli, SDa Pozzo, ECosta, BMarinelli, LLa Pietra, VNovellino, EMargarida Bernardo, MFridman, RDa Settimo, FMartini, CRossello, A Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur J Med Chem 46:2617-29 (2011) [PubMed]  Article 
Target
Name:
Matrix metalloproteinase-25
Synonyms:
Leukolysin | MMP-25 | MMP20 | MMP25 | MMP25_HUMAN | MMPL1 | MT-MMP 6 | MT6-MMP | MT6MMP | MTMMP6 | Matrix metalloproteinase-25 | Membrane-type matrix metalloproteinase 6 | Membrane-type-6 matrix metalloproteinase | Membrane-type-6 matrix metalloproteinase (MT6-MMP)
Type:
Protein
Mol. Mass.:
62564.84
Organism:
Homo sapiens (Human)
Description:
Q9NPA2
Residue:
562
Sequence:
MRLRLRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTELGLPPGEEVDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSSGPRAPRPPKATPVSETCDCQCELNQAAGRWPAPIPLLLLPLLVGGVASR
  
Inhibitor
Name:
BDBM50346797
Synonyms:
CHEMBL1795351
Type:
Small organic molecule
Emp. Form.:
C18H20N2O4S2
Mol. Mass.:
392.492
SMILES:
CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)NCC(=O)NO
Structure:
Search PDB for entries with ligand similarity: