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Target
Matrix metalloproteinase-25
Ligand
BDBM50346803
Substrate
n/a
Meas. Tech.
ChEMBL_753772 (CHEMBL1799653)
IC50
3.4±n/a nM
Citation
 Nuti, E; Casalini, F; Santamaria, S; Gabelloni, P; Bendinelli, S; Da Pozzo, E; Costa, B; Marinelli, L; La Pietra, V; Novellino, E; Margarida Bernardo, M; Fridman, R; Da Settimo, F; Martini, C; Rossello, A Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur J Med Chem 46:2617-29 (2011) [PubMed]  Article 
Target
Name:
Matrix metalloproteinase-25
Synonyms:
Leukolysin | MMP-25 | MMP20 | MMP25 | MMP25_HUMAN | MMPL1 | MT-MMP 6 | MT6-MMP | MT6MMP | MTMMP6 | Matrix metalloproteinase-25 | Membrane-type matrix metalloproteinase 6 | Membrane-type-6 matrix metalloproteinase | Membrane-type-6 matrix metalloproteinase (MT6-MMP)
Type:
Protein
Mol. Mass.:
62564.84
Organism:
Homo sapiens (Human)
Description:
Q9NPA2
Residue:
562
Sequence:
MRLRLRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTELGLPPGEEVDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSSGPRAPRPPKATPVSETCDCQCELNQAAGRWPAPIPLLLLPLLVGGVASR
  
Inhibitor
Name:
BDBM50346803
Synonyms:
CHEMBL1795862
Type:
Small organic molecule
Emp. Form.:
C26H26N2O4S2
Mol. Mass.:
494.626
SMILES:
CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N1Cc2ccccc2C[C@@H]1C(=O)NO |r|
Structure:
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