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Target
Type 1 fimbiral adhesin FimH
Ligand
BDBM50347450
Substrate
n/a
Meas. Tech.
ChEMBL_755506 (CHEMBL1805067)
IC50
31000±n/a nM
Citation
 Klein, T; Abgottspon, D; Wittwer, M; Rabbani, S; Herold, J; Jiang, X; Kleeb, S; Lüthi, C; Scharenberg, M; Bezençon, J; Gubler, E; Pang, L; Smiesko, M; Cutting, B; Schwardt, O; Ernst, B FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation. J Med Chem 53:8627-41 (2010) [PubMed]  Article 
Target
Name:
Type 1 fimbiral adhesin FimH
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
31430.55
Organism:
Escherichia coli (strain UTI89 / UPEC)
Description:
ChEMBL_755506
Residue:
300
Sequence:
MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPAVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGAAYGGVLSSFSGTVKYNGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ
  
Inhibitor
Name:
BDBM50347450
Synonyms:
CHEMBL1802194
Type:
Small organic molecule
Emp. Form.:
C20H21ClO8
Mol. Mass.:
424.829
SMILES:
COC(=O)c1ccc(cc1)-c1ccc(Cl)c(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)c1 |r|
Structure:
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