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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50241727
Substrate
n/a
Meas. Tech.
ChEMBL_754733 (CHEMBL1805588)
Ki
7000±n/a nM
Citation
 Dolušic, E; Larrieu, P; Blanc, S; Sapunaric, F; Pouyez, J; Moineaux, L; Colette, D; Stroobant, V; Pilotte, L; Colau, D; Ferain, T; Fraser, G; Galleni, M; Frère, JM; Masereel, B; Van den Eynde, B; Wouters, J; Frédérick, R Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. Eur J Med Chem 46:3058-65 (2011) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50241727
Synonyms:
(S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid | 1-Methyl-Tryptophan | 1-methyltryptophan | CHEMBL504816 | L-1-methyl-tryptophan
Type:
Small organic molecule
Emp. Form.:
C12H14N2O2
Mol. Mass.:
218.2518
SMILES:
Cn1cc(C[C@H](N)C(O)=O)c2ccccc12 |r|
Structure:
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