Reaction Details Report a problem with these data
Target
Transcriptional activator protein LasR
Ligand
BDBM50351251
Substrate
n/a
Meas. Tech.
ChEMBL_764352 (CHEMBL1820904)
IC50
30±n/a nM
Citation
 Malladi, VL; Sobczak, AJ; Maricic, N; Murugapiran, SK; Schneper, L; Makemson, J; Mathee, K; Wnuk, SF Substituted lactam and cyclic azahemiacetals modulate Pseudomonas aeruginosa quorum sensing. Bioorg Med Chem 19:5500-6 (2011) [PubMed]  Article 
Target
Name:
Transcriptional activator protein LasR
Synonyms:
LASR_PSEAE | lasR
Type:
PROTEIN
Mol. Mass.:
26618.24
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_1475312
Residue:
239
Sequence:
MALVDGFLELERSSGKLEWSAILQKMASDLGFSKILFGLLPKDSQDYENAFIVGNYPAAWREHYDRAGYARVDPTVSHCTQSVLPIFWEPSIYQTRKQHEFFEEASAAGLVYGLTMPLHGARGELGALSLSVEAENRAEANRFMESVLPTLWMLKDYALQSGAGLAFEHPVSKPVVLTSREKEVLQWCAIGKTSWEISVICNCSEANVNFHMGNIRRKFGVTSRRVAAIMAVNLGLITL
  
Inhibitor
Name:
BDBM50351251
Synonyms:
CHEMBL1818523
Type:
Small organic molecule
Emp. Form.:
C15H28N4O2
Mol. Mass.:
296.4084
SMILES:
CCCCCCCCCCCCn1nnc(CC(O)=O)n1
Structure:
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