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Target
Transcriptional activator protein LasR
Ligand
BDBM50351505
Substrate
n/a
Meas. Tech.
ChEMBL_765230 (CHEMBL1827783)
IC50
45200±n/a nM
Citation
 Lowery, CA; Salzameda, NT; Sawada, D; Kaufmann, GF; Janda, KD Medicinal chemistry as a conduit for the modulation of quorum sensing. J Med Chem 53:7467-89 (2010) [PubMed]  Article 
Target
Name:
Transcriptional activator protein LasR
Synonyms:
LASR_PSEAE | lasR
Type:
PROTEIN
Mol. Mass.:
26618.24
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_1475312
Residue:
239
Sequence:
MALVDGFLELERSSGKLEWSAILQKMASDLGFSKILFGLLPKDSQDYENAFIVGNYPAAWREHYDRAGYARVDPTVSHCTQSVLPIFWEPSIYQTRKQHEFFEEASAAGLVYGLTMPLHGARGELGALSLSVEAENRAEANRFMESVLPTLWMLKDYALQSGAGLAFEHPVSKPVVLTSREKEVLQWCAIGKTSWEISVICNCSEANVNFHMGNIRRKFGVTSRRVAAIMAVNLGLITL
  
Inhibitor
Name:
BDBM50351505
Synonyms:
CHEMBL1823935
Type:
Small organic molecule
Emp. Form.:
C18H28N2O4S
Mol. Mass.:
368.491
SMILES:
O=C(CCCCCCCCCCN=C=S)CC(=O)N[C@H]1CCOC1=O |r|
Structure:
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