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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50352652
Substrate
n/a
Meas. Tech.
ChEMBL_766795 (CHEMBL1827735)
IC50
7.59±n/a nM
Citation
 Seo, HJ; Park, EJ; Kim, MJ; Kang, SY; Lee, SH; Kim, HJ; Lee, KN; Jung, ME; Lee, M; Kim, MS; Son, EJ; Park, WK; Kim, J; Lee, J Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter. J Med Chem 54:6305-18 (2011) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50352652
Synonyms:
CHEMBL1823195
Type:
Small organic molecule
Emp. Form.:
C27H34FN5O2
Mol. Mass.:
479.5896
SMILES:
Cc1nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(C)c2C)c(C)n1-c1ccccc1F |(17.63,-21.49,;18.4,-20.16,;19.94,-20.16,;20.42,-18.7,;21.76,-17.93,;21.76,-16.39,;23.09,-18.7,;24.42,-17.93,;25.76,-18.7,;25.76,-20.24,;27.09,-17.93,;28.42,-18.69,;29.74,-17.91,;31.07,-18.68,;31.08,-20.22,;29.75,-20.99,;28.41,-20.23,;32.41,-20.98,;33.75,-20.2,;35.08,-20.97,;35.09,-22.51,;33.75,-23.28,;33.75,-24.82,;32.42,-22.52,;31.08,-23.29,;19.17,-17.79,;19.17,-16.25,;17.93,-18.7,;16.6,-17.92,;16.6,-16.38,;15.27,-15.61,;13.93,-16.38,;13.93,-17.93,;15.27,-18.69,;15.27,-20.23,)|
Structure:
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