Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50359095
Substrate
n/a
Meas. Tech.
ChEMBL_789497 (CHEMBL1924524)
IC50
0.700000±n/a nM
Citation
 Stock, NSBain, GZunic, JLi, YZiff, JRoppe, JSantini, ADarlington, JProdanovich, PKing, CDBaccei, CLee, CRong, HChapman, CBroadhead, ALorrain, DCorrea, LHutchinson, JHEvans, JFPrasit, P 5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor. J Med Chem 54:8013-29 (2011) [PubMed]  Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50359095
Synonyms:
CHEMBL1922524
Type:
Small organic molecule
Emp. Form.:
C39H40N4O4S
Mol. Mass.:
660.824
SMILES:
COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4cnc5ccccc5n4)ccc23)cc1
Structure:
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